BASIC Exam Sample Questions
1. Which of the following nerves should MOST likely be blocked for an operation at the medial
aspect of the lower leg?
A. Femoral
B. Common peroneal
C. Tibial
2. A patient is scheduled to undergo laparoscopic cholecystectomy. Thirty minutes after receiving
premedication with morphine and midazolam, she suddenly develops right upper quadrant
abdominal pain and nausea. Which of the following drugs is the MOST appropriate therapy for
this patient’s pain?
A. Flumazenil
B. Ketorolac
C. Naloxone
3. A 68-year-old woman with primary hyperparathyroidism is scheduled to undergo
parathyroidectomy. Her serum calcium concentration is 15 mg/dL. IV administration of which of
the following substances is the MOST appropriate initial management?
A. Magnesium sulfate
B. Normal saline
C. Methylprednisolone
4. Which of the following tests MOST reliably predicts the likelihood that a patient will develop
malignant hyperthermia?
A. Calcium uptake assay in skeletal muscle biopsy
B. Genetic testing of the ryanodine receptor
C. Caffeine-halothane contracture test
5. O
2
100 mL/min is bubbled through a vaporizer containing an anesthetic with a vapor pressure
of 150 mmHg, and this mixture is added to a fresh gas flow of 5 L/min. Which of the following
values BEST represents the delivered anesthetic concentration?
A. 0.25%
B. 0.5%
C. 2.5%
2
6. An adult patient with mild hypothermia is anesthetized with 1 MAC of isoflurane. Which of the
following physiologic mechanisms is MOST effective for maintaining body temperature in this
patient?
A. Nonshivering thermogenesis
B. Shivering thermogenesis
C. Vasoconstriction
7. A 72-year-old man has just received midazolam for an endoscopic procedure of the upper
gastrointestinal tract. Sedation is easily antagonized by flumazenil. Although the endoscopist
asks to send the patient home in 1 hour, which of the following factors BEST explains why this
patient should remain hospitalized for observation?
A. Flumazenil has low affinity for benzodiazepine receptors
B. Flumazenil has moderate intrinsic agonist activity
C. Midazolam has a longer duration of action than flumazenil
8. Which of the following factors exerts the GREATEST effect on the extent of spread of local
anesthetic following subarachnoid block with hyperbaric bupivacaine?
A. Added epinephrine
B. Patient position
C. Total dose of drug
9. A 17-year-old boy develops pulmonary edema after resolution of postoperative laryngospasm.
While breathing 100% O
2
, SpO
2
is 80%. Which of the following strategies is the MOST
appropriate management?
A. Administration of albuterol
B. Administration of furosemide
C. Positive-pressure ventilation
10. A 61-year-old man receives a spinal anesthetic for transurethral resection of the prostate
(TURP). Forty-five minutes after the start of the procedure, he suddenly develops nausea,
diaphoresis, and sharp pain in the left shoulder. Which of the following etiologies is the MOST
likely cause?
A. Angina pectoris
B. Bladder perforation
C. Inadequate spinal sensory level
11. A 36-year-old woman is receiving general anesthesia for a diagnostic laparoscopy in the
Trendelenburg position with CO
2
insufflation. During a 15-minute period after induction, her
SpO
2
decreases from 99% to 90% and the partial pressure of ETCO
2
increases from 38 to 43
3
mmHg. FiO
2
is 0.3; all ventilator settings have been constant. Which of the following etiologies
is the MOST likely cause of the decrease in SpO
2
?
A. CO
2
embolus
B. Compression of the vena cava
C. Right mainstem endobronchial intubation
12. Two hours after a laparoscopic cholecystectomy, a 45-year-old woman with obesity is
receiving IV PCA with morphine. Her SpO
2
is 90% on room air. Which of the following
etiologies is the MOST likely cause of her hypoxemia?
A. Absorption of CO
2
from the abdomen
B. Hypoventilation
C. Increased dead space
13. In a patient receiving pressure support ventilation, pressure support breaths are triggered by
which of the following preset factors?
A. A decrease in airway pressure
B. An increase in airway pressure
C. An increase in inspiratory flow rate
14. A healthy 42-year-old man has an increase in heart rate from 60 bpm to 120 bpm during
induction of anesthesia. Which of the following factors is MOST likely to satisfy the increased
metabolic demand of the myocardium?
A. Decreased coronary artery resistance
B. Increased coronary perfusion pressure
C. Increased O
2
extraction by the myocardium
15. Which of the following laboratory values is MOST likely to confirm adequate synthetic hepatic
function?
A. Partial thromboplastin time
B. Prothrombin time
C. Serum alanine aminotransferase concentration
16. Which of the following strategies BEST prevents ventricular dysrhythmias in a patient
undergoing extracorporeal shock wave lithotripsy?
A. Beta-adrenergic blockade
B. ECG synchronization
C. Epidural blockade to T4
4
17. Compared with a semiclosed circle system, a Bain circuit exhibits which of the following
characteristics?
A. Less rebreathing of CO
2
B. A lower fresh gas flow requirement
C. More rapid change in inspired gas concentration
18.
The capnograph waveform shown above was obtained from a patient undergoing hip surgery
in the lateral position. Which of the following BEST explains the findings between point A and
point B?
A. Excessive tidal volume
B. Incompetent expiratory valve
C. Patient position
19. A 67-year-old man who developed a rash with past administration of penicillin is undergoing
open reduction of a femur fracture. The surgeon asks if cefazolin can be administered to this
patient. Which of the following actions is MOST appropriate for the anesthesiologist to
perform?
A. Administer cefazolin
B. Administer hydrocortisone, followed by cefazolin
C. Administer vancomycin instead of cefazolin
20. Which of the following factors DECREASES the MAC of isoflurane?
A. Acute cocaine intoxication
B. Chronic ethanol abuse
C. Symptomatic hyponatremia
21. Which of the following outcomes BEST describes the primary toxic effect of bupivacaine on the
cardiovascular system?
A. Blockade of norepinephrine release
B. Coronary vasoconstriction
5
C. Delay of ventricular repolarization
22. Which of the following conditions MOST likely causes a rightward shift in the oxyhemoglobin
dissociation curve?
A. Carboxyhemoglobinemia
B. Decreased 2,3-diphosphoglycerate concentration
C. Hyperthermia
23. Which of the following findings is most likely to be DECREASED in a patient with clinical
hypothyroidism?
A. MAC
B. Myocardial contractility
C. Peripheral vascular tone
24. Which of the following anesthetic drugs is MOST likely to be associated with longer seizure
duration when used for electroconvulsive therapy?
A. Etomidate
B. Methohexital
C. Propofol
25. Which of the following drugs does NOT cause enhanced activity of the GABA receptor?
A. Etomidate
B. Ketamine
C. Propofol
26.
Which of the following systems will MOST likely prevent rebreathing of CO
2
regardless of the
mode of ventilation?
A. A
6
B. B
C. C
27.
Which of the following components is MISPLACED in the circle system shown in the above
illustration?
A. Fresh gas inlet
B. CO
2
absorber
C. Expiratory valve
28. A new IV anesthetic is found to have a very large volume of distribution. This drug is MOST
likely to have which of the following properties?
A. Low lipid solubility
B. High rate of ionization
C. Low plasma protein binding
29. Which of the following drugs has the LONGEST duration of action in a patient with renal
failure?
A. Neostigmine
B. Rocuronium
C. Succinylcholine
30. Instillation of local anesthetic into the trachea via the cricothyroid membrane is MOST likely to
block which of the following nerves?
A. Hypoglossal
B. Internal branch of the superior laryngeal
C. Recurrent laryngeal
31. Gagging that occurs during awake intubation is BEST prevented by local anesthetic block of
which of the following nerves?
7
A. Superior laryngeal
B. Glossopharyngeal
C. Hypoglossal
32. Which of the following factors is the MOST likely explanation for the initial reduction in core
temperature during general anesthesia?
A. Ablation of thermoregulatory vasoconstriction
B. Evaporative heat loss in the respiratory tract
C. Redistribution of heat from the core to the periphery
33. A 65-kg, 70-year-old man in the PACU is breathing spontaneously at 20 breaths/minute
through an ETT connected to a T-piece with a fresh gas flow of 5 L/min and an FiO
2
of 0.5. His
tidal volume is 350 mL. Over 1 hour, his SpO
2
decreases from 98% to 84%, and then improves
to 92% when FiO
2
is increased to 1.0. Which of the following etiologies is the MOST likely
cause of his hypoxemia?
A. Decreased FRC
B. Increased dead space ventilation
C. Room air admixture during inspiration
34. A 40-year-old man who is scheduled for repair of a tendon laceration of the left hand has
complete anesthesia in the median, radial, and ulnar nerve distributions after supraclavicular
block. Two hours of tourniquet inflation are required for completion of the procedure. The most
appropriate NEXT step is an additional block of which of the following nerves?
A. Axillary
B. Intercostobrachial
C. Musculocutaneous
35. Which of the following mechanisms is PRIMARILY responsible for emergence after a single
dose of propofol?
A. Redistribution
B. Metabolism
C. Excretion
36. An anesthesia machine is set to deliver O
2
2 L/min, nitrous oxide 2 L/min, and sevoflurane.
After 30 minutes of stable anesthesia, which of the following complications is the most likely
cause of a DECREASE in the O
2
analyzer reading from 50% to 30%?
A. A leak in the ventilator bellows
B. Accumulation of water on the O
2
sensor membrane
C. Presence of the O
2
analyzer in the expiratory limb
8
37. An induction dose of ketamine is MOST likely to have which of the following effects?
A. Analgesia
B. Decreased cerebral metabolic rate
C. Preservation of laryngeal reflexes
38. As compared with an IV dose of morphine, which of the following factors is the most likely
explanation for the DECREASED duration of action of an IV dose of fentanyl?
A. Greater lipid solubility
B. Increased hepatic metabolism
C. Shorter elimination half-life
39. Which of the following definitions BEST describes what the standard error of the mean shows?
A. The precision of the population mean
B. The range of the sample values
C. The deviation about the median of the study group
40. Pulse oximetry accurately reflects SaO
2
in which of the following situations?
A. Administration of indocyanine green
B. Carboxyhemoglobinemia
C. 40% fetal hemoglobin concentration
41. A patient with a fasting blood glucose of 100 mg/dL is receiving a 4-hour general anesthetic for
repair of tendon lacerations. Which of the following blood glucose concentrations is MOST
likely expected on emergence?
A. Marked hypoglycemia
B. Mild hyperglycemia
C. Mild hypoglycemia
42. Which of the following drugs INCREASES gastric pH while decreasing gastric volume?
A. Glycopyrrolate
B. Metoclopramide
C. Ranitidine
43. Which of the following characteristics of nitrous oxide MOST likely explains why its alveolar
and inspired concentrations equilibrate more rapidly than those of desflurane?
A. Delivery at a higher inspired concentration
9
B. Creation of a second gas effect
C. Lower blood gas solubility
44. Which of the following goals is the PRIMARY purpose of denitrogenation prior to anesthetic
induction?
A. Improving matching of ventilation and perfusion
B. Increasing O
2
reserve in the FRC
C. Maximizing arterial O
2
content
45. A 32-year-old woman sustains an injury to the left recurrent laryngeal nerve during
thyroidectomy. Which of the following postoperative findings is MOST likely in this patient?
A. Adduction of the left vocal cord at rest
B. Aphonia
C. Aspiration caused by glottic incompetency
46. Which of the following values, in mmHg, is the expected mixed venous O
2
tension in a normal
adult after breathing 100% O
2
for 10 minutes?
A. 45
B. 95
C. 150
47. Which of the following drugs has the SHORTEST elimination half-life?
A. Flumazenil
B. Lorazepam
C. Midazolam
BASIC Exam Answer Key
Question # Key Question # Key Question # Key Question # Key
1 A 13 A 25 B 37 A
2 C 14 A 26 B 38 A
3 B 15 B 27 A 39 A
4 C 16 B 28 C 40 C
5 B 17 C 29 A 41 B
6 C 18 C 30 C 42 C
7 C 19 A 31 B 43 A
8 B 20 C 32 C 44 B
9 C 21 C 33 A 45 A
10 B 22 C 34 B 46 A
11 C 23 B 35 A 47 A
12 B 24 A 36 B